Inhibition of CDK9 alleviates osteoarthritis by suppressing inflammation and reducing chondrocyte apoptosis
Our findings demonstrate that CDK9 plays a critical role in PTOA pathogenesis. Inhibition of CDK9 alleviates disease progression by suppressing the NF-κB signaling pathway, highlighting its potential as a therapeutic target for PTOA.
Authors
- Yuhu Zhao
- Zhiyi Wu (ORCID: https://orcid.org/0000-0002-3215-0092)
- Po Zhang (ORCID: https://orcid.org/0000-0001-7847-9478)
- Haibo Xu (ORCID: https://orcid.org/0000-0003-0493-5148)
- Wei J. Wang (ORCID: https://orcid.org/0000-0002-4848-7394)
- Bo Zhang
- Yaozeng Xu
Institutions
- Xuzhou Medical College (CN)
- Soochow University (TW)
- Nantong University (CN)
- Soochow University (CN)
- Affiliated Hospital of Nantong University (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fphar.2026.1784174
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Priority Academic Program Development of Jiangsu Higher Education Institutions