Exploring hub genes related to adipocytokines in keloids: a combined analysis integrating single-cell, Mendelian randomization and bulk transcriptome data with experimental verification

This study, based on the integrated re-analysis of existing publicly available transcriptomic data and combined with clinical sample validation, revealed the potential hub roles of PIK3R3 and ANGPTL5 in keloid pathogenesis. PIK3R3 was validated as a causal hub gene, while ANGPTL5 also showed relevance. The study provides new molecular evidence and mechanistic insights for understanding the adipocytokine-related pathological mechanisms of keloids, and suggests potential therapeutic directions such as harmine for future research.