Two-Stage Prepectoral Breast Reconstruction with and without Acellular Dermal Matrix: A Cluster-Randomized Noninferiority Trial
Two-stage prepectoral breast reconstruction with ADM was noninferior to reconstruction without ADM regarding major 90-day postoperative complications, with comparable minor complications, patient-reported outcomes, and pain. These findings support the routine use of ADM as a safe option. Long-term follow-up comparing relevant clinical outcomes is needed to clarify the benefits of ADM.Trial Registration: Clinicaltrials.gov NCT05316324.
Authors
- Danielle H. Rochlin (ORCID: https://orcid.org/0000-0003-4743-3455)
- Carrie Scharf Stern
- Ronnie Labib Shammas (ORCID: https://orcid.org/0000-0001-5468-8646)
- Colleen M. McCarthy
- Joseph J. Disa
- Babek Mehrara
- Mithat Gönen (ORCID: https://orcid.org/0000-0001-8683-8477)
- Lillian A. Boe (ORCID: https://orcid.org/0000-0001-6279-9987)
- Michelle Coriddi (ORCID: https://orcid.org/0000-0001-5530-5862)
- Jonas A. Nelson (ORCID: https://orcid.org/0000-0003-0329-4422)
- Evan Matros
Institutions
- Memorial Sloan Kettering Cancer Center (US)
Publication Details
- Journal
- Plastic & Reconstructive Surgery
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1097/prs.0000000000013019
- Primary Topic
- Breast Implant and Reconstruction
- Type
- article
- Field-Weighted Citation Impact
- 0.00