Optic Nerve Head Spatial Transcriptomic Change in Nonhuman Primate Early Experimental Glaucoma
Spatial transcriptomics analysis revealed a consistent downregulation of multiple myelin-related genes, and IHC confirmed a corresponding decrease in CNPase protein expression. Importantly, spatial transcriptomics identified differential profiles among the prelaminar, laminar, and retrolaminar ONH. Together, these findings highlight early myelin disruption and provide insights into the spatial and molecular dynamics of disease onset in NHP. This work advances our understanding of glaucoma pathogenesis and lays the groundwork for developing novel therapeutic strategies.
Authors
- Galen Williams
- Claude F. Burgoyne (ORCID: https://orcid.org/0000-0002-2765-4739)
- J. Jack Lee (ORCID: https://orcid.org/0000-0001-5469-9214)
- Juan Reynaud
- Hongli Yang
- Nicholas Marsh-Armstrong
- Gabriel Zangirolani
- Priya Chaudhary
Institutions
- Legacy Health (US)
- Oregon Health & Science University (US)
- University of California, Davis (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1167/iovs.67.3.22
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Oregon Health and Science University
- American Glaucoma Society
- Good Samaritan Foundation
- National Institutes of Health
- Knight Cancer Institute, Oregon Health and Science University
- National Eye Institute
- Alcon Research Institute