Propionate attenuates osteoarthritis progression by regulating the gut-joint axis
Propionate, a gut-derived SCFA, alleviated pain, protected cartilage, reduced inflammation, restored gut barrier integrity, and rebalanced microbiota in OA rats. In human OA chondrocytes, it upregulated ECM-related genes, downregulated inflammatory mediators, and enhanced autophagy. These findings suggest that propionate may serve as a promising disease-modifying therapy for OA.
Authors
- Hyun Sik Na (ORCID: https://orcid.org/0000-0003-3436-2694)
- Jeong Won Choi
- JooYeon Jhun (ORCID: https://orcid.org/0000-0003-3953-669X)
- Seok jung Kim
- M. Cho
- Keun-Hyung Cho (ORCID: https://orcid.org/0000-0001-9460-1971)
- Young‐Mee Moon
- Serdar Han
Institutions
- The Catholic University of Korea Uijeongbu St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fimmu.2026.1717556
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00