Tetrahydropalmatine alleviates cancer induced bone pain by inhibiting TRPV1-SP-mediated macrophage recruitment and promoting M2 polarization
In conclusion, THP mitigates CIBP through a dual mechanism: regulating macrophage recruitment via the TRPV1-SP pathway in the early stage to inhibit CIBP initiation and directly modulating the migrated macrophage polarization. This study provides novel insights into THP's analgesic mechanisms and supports its potential as a preclinical candidate for CIBP treatment.
Authors
- Lan Zhou (ORCID: https://orcid.org/0000-0002-1748-2347)
- Guang Yu (ORCID: https://orcid.org/0000-0001-7918-0160)
- Yucui Jiang
- Qi Zhang (ORCID: https://orcid.org/0000-0001-5803-2556)
- Hanwen Wang (ORCID: https://orcid.org/0000-0003-1277-0742)
- Changming Wang
- Zongxiang Tang
- Qingyong Yu
- Ziyun Chen
Institutions
- Nanjing University of Chinese Medicine (CN)
- Hainan Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1186/s13020-026-01359-3
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing University of Chinese Medicine
- Nanjing University
- Priority Academic Program Development of Jiangsu Higher Education Institutions