Association between glucagon-like peptide-1 receptor agonists and femur fracture risk in type 2 diabetes: A large-scale target trial emulation

GLP-1 RA use was associated with a modest reduction in femur fracture risk. However, given the observational design, possible residual confounding, and multiple testing, these findings are exploratory and require prospective confirmation before clinical application.

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Publication Details

Journal
Bone
Published
2026-03-11
DOI
https://doi.org/10.1016/j.bone.2026.117851
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Association between glucagon-like peptide-1 receptor agonists and femur fracture risk in type 2 diabetes: A large-scale target trial emulation

Jie-Fan Chang, Mengting Chen, Chiou-Shann Fuh, Yao-Jen Chang et al.
Bone
Diabetes Treatment and Management
article

Association between glucagon-like peptide-1 receptor agonists and femur fracture risk in type 2 diabetes: A large-scale target trial emulation

Jie-Fan Chang, Mengting Chen, Chiou-Shann Fuh, Yao-Jen Chang, Ming-Hsien Tsai
article en

Abstract

GLP-1 RA use was associated with a modest reduction in femur fracture risk. However, given the observational design, possible residual confounding, and multiple testing, these findings are exploratory and require prospective confirmation before clinical application.

BoneVol. 207
National Taiwan University (TW), National Taiwan University Hospital (TW), Memorial Hospital (US)
Openalex Percentile: Top 27%
Diabetes Treatment and Management
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