Liver–metabolic stress, apolipoprotein E ε4, and cognition and amyloid burden: findings from the dementia platform Korea trial-ready registry
Routine liver-metabolic indices were associated with cognitive performance, while FIB-4 stage showed effect modification by APOE ε4 in relation to both cognition and amyloid PET SUVR. These findings support heterogeneity in liver-metabolic and genetic contributions to late-life cognitive vulnerability in a dementia trial-ready registry and motivate longitudinal studies to clarify temporal relationships.
Authors
- S. H. Lee
- 김대진 (ORCID: https://orcid.org/0000-0001-6675-5607)
- Young Hyun Jung (ORCID: https://orcid.org/0000-0002-2308-6308)
- Young Hyeon Ahn (ORCID: https://orcid.org/0000-0003-0773-9409)
- Chan-Mo Yang (ORCID: https://orcid.org/0000-0002-4959-7595)
- DaHyeon Choi
- Sae Hwan Lee
- Sung-Hoon Yoon
- Jin Gu Kang
Institutions
- Soonchunhyang University (KR)
- Soonchunhyang University Hospital Seoul (KR)
- Wonkwang University (KR)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fnagi.2026.1773977
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Soonchunhyang University
- Wonkwang University
- National Research Foundation of Korea