Downregulation of Organ‐Derived Activin A Attenuates Muscle Atrophy and Intramuscular Fat Infiltration in Cancer Cachexia Mice
Simultaneous downregulation of Activin A in the kidney and heart attenuates skeletal muscle atrophy and intramuscular adipogenesis, improves muscle mass and function and mitigates adipose tissue mass loss in cancer cachexia mice. These findings identify heart- and kidney-derived Activin A as a key driver of cachexia, which acts through a combinatorial effect rather than an isolated contribution from either one alone, highlighting its potential as a therapeutic target.
Authors
- C. B. Wang
- Honghui Li (ORCID: https://orcid.org/0009-0003-1134-2874)
- John R. Speakman (ORCID: https://orcid.org/0000-0002-2457-1823)
- Wenbo Yang (ORCID: https://orcid.org/0000-0002-7689-1968)
- Lin Gao (ORCID: https://orcid.org/0000-0001-6396-0787)
- Rui Xue (ORCID: https://orcid.org/0000-0003-1531-0258)
- Jia Su (ORCID: https://orcid.org/0000-0002-2123-9753)
- Yuqi Zhu (ORCID: https://orcid.org/0009-0007-1299-1744)
- Xiao Tang (ORCID: https://orcid.org/0009-0009-6088-9095)
- Xina Xie
- Yan Tang (ORCID: https://orcid.org/0009-0001-4950-8011)
- Zesong Li
- Shasha Min
- Bo Mu
- Zhihang Su
Institutions
- North Sichuan Medical University (CN)
- Sun Yat-sen University (CN)
- Shantou University (CN)
- Longgang Central Hospital (CN)
- Yue Bei People's Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1002/jcsm.70237
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00