Efficacy and safety of autologous cell-based therapies for atrophic acne scar treatment: an updated systematic review and meta-analysis with in-depth methodological and clinical insights

Autologous cell-based therapies, particularly SVF, are effective and safe for improving atrophic acne scars, offering superior clinical, patient-reported, and safety outcomes compared to standard controls. The integration of detailed methodological insights provides a valuable evidence base to guide clinical protocol optimization and future research focused on standardization and long-term efficacy.