A visible assay for evaluating the inhibitory activity of drug and antibody against HBV infection
In this study, we report a sensitive and reliable immunospot assay for the visible quantitative detection of HBV infection. This assay demonstrates excellent performance in evaluating the inhibitory effect of antiviral drugs, neutralizing antibodies, and plasma samples from vaccinated individuals. Given its robustness and versatility, the proposed method is anticipated to be an excellent alternative assay for HBV-related research, including therapeutic development and vaccine evaluation.
Authors
- Huimin Guo (ORCID: https://orcid.org/0009-0007-0490-2289)
- Yuxiao Li
- Yufeng Liu (ORCID: https://orcid.org/0000-0002-7742-7307)
- Hu Yan
- C Liu
- Haiyan Wang
- Zheng Zhang
- Xiangyang Ge
- Bin Ju
Institutions
- Academy of Medical Sciences (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Southern University of Science and Technology (CN)
- National Clinical Research (US)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1128/spectrum.02638-25
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00