CT Histogram Analysis for Predicting Malignancy in Anterior Mediastinal Masses

CT histogram analysis, particularly mean attenuation, may serve as a complementary biomarker for differentiating benign from malignant anterior mediastinal masses. Given its high sensitivity but limited specificity, it should be used as an adjunct to clinical and morphologic assessment rather than as a determinant of surgical management. Prospective validation incorporating volumetric and advanced radiomic parameters is required.