Dissolvable silk microneedles delivering minocycline-loaded ZIF-8 nanoparticles for targeted modulation of sebocyte metabolism and improved acne therapy
Collectively, this study establishes a nanobiotechnology platform that integrates metal-organic frameworks(MOF)-based pH-responsive delivery with antibacterial, anti-inflammatory, and metabolic reprogramming activities, offering a precise and minimally invasive multimodal strategy for sebaceous gland-targeted acne therapy.
Authors
- Xuefan Yang
- Xinlan Qiu
- Xiping Jiang (ORCID: https://orcid.org/0000-0002-9103-0891)
- Xiaohui Mo
- Dandan Ruan
- Qiang Ju
- Lei Huang
- Christos C Zouboulis
- Sitong Li
- Feng Ye
Institutions
- Peking University (CN)
- Renji Hospital (CN)
- Peking University Third Hospital (CN)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1186/s12951-026-04221-8
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00