Exosomal Lnc-DLK1-35 reprograms microglia into a pro-tumorigenic phenotype via a non-canonical cytokine signature to promote glioblastoma progression and chemoresistance
Exosomal Lnc-DLK1-35 reprograms cultured microglia cells into a pro-tumorigenic state via a non-canonical cytokine signature, driving TMZ resistance and invasion. Targeting this axis disrupts microglia-GBM communication, revealing a novel therapeutic strategy.
Authors
- Xuan Zheng (ORCID: https://orcid.org/0000-0001-9147-2828)
- Yongliang Liu (ORCID: https://orcid.org/0000-0002-1492-8374)
- Jianxiong Guo (ORCID: https://orcid.org/0000-0003-3417-3164)
- Ye Li (ORCID: https://orcid.org/0000-0002-0255-3915)
- Di Li (ORCID: https://orcid.org/0000-0002-3371-3344)
- Yuhui Li (ORCID: https://orcid.org/0000-0002-6070-5390)
- Jingwu Li (ORCID: https://orcid.org/0000-0001-7714-254X)
- Zhuo Wang
- Yang Wang
Institutions
- Hospital of Hebei Province (CN)
- Tangshan People's Hospital (CN)
- TED University (TR)
Publication Details
- Journal
- Folia Histochemica et Cytobiologica
- Published
- 2026-03-11
- DOI
- https://doi.org/10.5603/fhc.109684
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00