Multi-omics study on tumor-associated macrophages remodeling the tumor microenvironment via the CXCL5-CXCR2 axis to drive immune escape in bladder cancer
The CXCL5-CXCR2 axis mediates bladder cancer cell-macrophage crosstalk: macrophages promote tumor growth, immune escape, and cisplatin tolerance; tumor cells induce macrophage polarization and reshape immunosuppressive TME. Additionally, this axis drives bladder cancer malignant progression and enhances immunotherapy efficacy.
Authors
- Minxuan Jing
- Yuanchun Pu (ORCID: https://orcid.org/0000-0002-6507-5316)
- Jiale He (ORCID: https://orcid.org/0000-0002-0535-6685)
- Jinhai Fan
- Yirong Jiang
- Zezhong Yang
- Mengzhao Zhang
- Yaodong Zhang
- Xiaowei Qu
- Lu Wang
- Lu Zhang
- Jianpeng Li (ORCID: https://orcid.org/0009-0007-1203-4960)
- Minghai Ma
- Hang Liu
- Yutong Chen
Institutions
- Nanchang University (CN)
- Shanghai Cancer Institute (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Hospital of Xi'an (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1007/s00262-026-04353-8
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00