Distinct Blood and Lung Proteins Drive Pulmonary Capillary Leak in Children With Severe Hypoxemic Respiratory Failure
These unexpected findings reveal that blood and lung compartments contain differentially abundant proteins that exert distinct and evolving influences on pulmonary endothelial integrity in critically ill children. These results may inform on the timing and compartment-specific assessment of biomarkers, and eventually, delivery of therapies.
Authors
- Steven Bruzek (ORCID: https://orcid.org/0000-0002-2454-4446)
- Jordan S. Pober (ORCID: https://orcid.org/0000-0001-5990-1071)
- Richard W. Pierce (ORCID: https://orcid.org/0000-0001-5941-8805)
- Vera Ignjatović (ORCID: https://orcid.org/0000-0002-5548-5813)
- Angeliki Gkaifyllia
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Yale University (US)
- Johns Hopkins All Children's Hospital (US)
- Stony Brook University (US)
Publication Details
- Journal
- Pediatric Critical Care Medicine
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1097/pcc.0000000000003934
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00