Whole blood storage time impairs clot strength with minimal change in functional fibrinogen concentration
Fibrinogen did not undergo detectable proteolysis during storage of WB and had preserved function through day 35 after freeze-thaw cycles to minimize platelet contributions. NLR appeared to impact fibrinogen function with medians below 200 for day 21 and 35 but was not statistically significant. This suggests that previously reported reductions in fibrinogen function may be based on leukoreduction status, but that early changes in fibrinolysis sensitivity are more likely due to residual platelet contributions to the assays rather than loss of fibrinogen function itself.
Authors
- Shelly M. Williams (ORCID: https://orcid.org/0000-0002-0398-2359)
- Christopher D. Barrett (ORCID: https://orcid.org/0000-0001-9720-8155)
- Susan M. Shea (ORCID: https://orcid.org/0000-0003-3756-2747)
- Scott A. Koepsell (ORCID: https://orcid.org/0000-0002-5529-7054)
- Aleh Bobr (ORCID: https://orcid.org/0000-0003-1597-8071)
- Flobater I. Gawargi (ORCID: https://orcid.org/0000-0003-0877-4521)
- Nicolle K. Barmettler
- TR Billiar
- Refael Munitz
- Phillip C Spinella
- Reynold Henry
- Natasha Goodman
- Elizabeth R. Maginot
- Collin M. White
Institutions
- Nebraska Medical Center (US)
- Institute for Transfusion Medicine (US)
- University of Pittsburgh Medical Center (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Transfusion
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1111/trf.70150
- Primary Topic
- Blood transfusion and management
- Type
- article
- Field-Weighted Citation Impact
- 0.00