METTL3-driven m6A modification of NLRC5 promotes renal fibrosis in chronic kidney disease through Keap1/Nrf2/ARE signaling pathway
METTL3 promotes renal fibrosis by stabilizing NLRC5 mRNA via m<sup>6</sup>A modification, leading to suppression of the protective Keap1/Nrf2/ARE pathway. Targeting the METTL3/NLRC5/Keap1/Nrf2/ARE axis may represent a promising therapeutic strategy for CKD-associated fibrosis.
Authors
- Mingjiao Pan
- Na An
- Yafei Bai
- Mingzhi Xu
- Ruman Chen
- Chunli Wang
- Yonghui Qi
- Xin Zeng
Institutions
- Hainan General Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fimmu.2026.1739011
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00