Sodium pyruvate ameliorates cognitive dysfunction by expanding hippocampal endogenous neural stem cells in tBCCAO mice
According to our findings, the mechanisms by which SP enhances the growth of internal NSCs and the maturation of immature neurons may involve the p300-H3K9ac-DCX signaling pathway, suggesting a new therapeutic target for stroke recovery.
Authors
- Jia He (ORCID: https://orcid.org/0000-0002-2338-9501)
- Yan Gao (ORCID: https://orcid.org/0000-0001-6905-0143)
- Ge Yan
- Zican Wang
- Lici Yang
- Yongjian Jiang (ORCID: https://orcid.org/0000-0003-4652-4689)
- Pengyue Li (ORCID: https://orcid.org/0000-0003-3738-8662)
- Lili Yuan (ORCID: https://orcid.org/0000-0001-6595-3775)
- Dongyu Ding
- Zijia Liu
- Benjun Qi
- Wenwen Liu
- Yongwei Pan
Institutions
- Jining Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fcell.2026.1782699
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province