Functional properties of dorsolateral prefrontal cortex to primary motor cortex connectivity: a dual-site TMS study
This study confirms that, at rest, the bilateral DLPFC exerts a stable and non-specific facilitatory regulation on the left M1. This effect persists in the affected M1 of stroke patients, suggesting plasticity in the relevant pathways after injury. The negative findings for the right M1 reveal a lateralization characteristic in DLPFC-M1 regulation. These results provide an important basis for elucidating the physiological mechanisms of cognitive-motor circuits and for developing targeted neurorehabilitation strategies.
Authors
- Wan-Rong Xu
- Benguo Wang
- Ying-Rong Liu
- Ye Li (ORCID: https://orcid.org/0000-0001-7727-0875)
- Yong Li (ORCID: https://orcid.org/0000-0001-9939-094X)
- Yi Xue (ORCID: https://orcid.org/0000-0003-1576-7733)
- X. Sheldon Lin (ORCID: https://orcid.org/0009-0000-0686-5206)
- Rui Hong
- Jia-Wei Jiang
- Yu-Han Liu
Institutions
- Hubei University of Medicine (CN)
- Gannan Medical University (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Human Neuroscience
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fnhum.2026.1776794
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shenzhen Fundamental Research Program