Coexistence of blaNDM−1, blaIMP−4and blaOXA−181 in Citrobacter braakii clinical isolate in China
we isolated a C. braakii W221 co-existing bla<sub>NDM-1</sub>, bla<sub>IMP-4</sub>, and bla<sub>OXA-181</sub>, and this was first reported in the world. The presence of multiple transferrable and mobilizable plasmids carrying key resistance determinants suggested that this strain may have high potential for horizontal gene transfer and rapid dissemination. These findings suggesting that clinical settings should be vigilant against the further emergence, spread and prevalence of such novel multidrug-resistant strains.
Authors
- Huilin Zhao (ORCID: https://orcid.org/0009-0006-4449-354X)
- Weihua Han (ORCID: https://orcid.org/0009-0003-3285-3905)
- Ying Zhou
- Shanshan Wang
- Yanlei Xu
- Fangyou Yu
- Jiao Zhang
- Xiaocui Wu
- Bingjie Wang
Institutions
- Shanghai Pulmonary Hospital (CN)
- Ningbo University Affiliated Hospital (CN)
- Ningbo First Hospital (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1186/s12866-026-04941-9
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00