Impact of Tocilizumab on endothelial function following Out-of-Hospital Cardiac Arrest: A Substudy of the IMICA randomized controlled Trial

Plasma syndecan-1 decline was less pronounced in comatose OHCA patients treated with tocilizumab, without affecting sTM or PECAM-1. This contrasts previous IMICA findings of reduced systemic inflammation, vasopressor use, and myocardial injury, suggesting a complex relationship between inflammation and endothelial injury.Finally, PECAM-1 levels already at hospital admission had a moderate predictive value for mortality.

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Publication Details

Journal
European Heart Journal Acute Cardiovascular Care
Published
2026-03-08
DOI
https://doi.org/10.1093/ehjacc/zuag034
Primary Topic
Cardiac and Coronary Surgery Techniques
Type
article
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article

Impact of Tocilizumab on endothelial function following Out-of-Hospital Cardiac Arrest: A Substudy of the IMICA randomized controlled Trial

Pär I. Johansson, Zakaria Alaoui-Ismaili, Martin Frydland, A Meyer et al.
European Heart Journal Acute Cardiovascular Care
Cardiac and Coronary Surgery Techniques
article

Impact of Tocilizumab on endothelial function following Out-of-Hospital Cardiac Arrest: A Substudy of the IMICA randomized controlled Trial

Pär I. Johansson, Zakaria Alaoui-Ismaili, Martin Frydland, A Meyer, Laust E. R. Obling, Martin A. S. Meyer, Johannes Grand, Sebastian Wiberg, Jesper Kjaergaard, Yassin Alaoui-Ismaili, Christian Hassager
article en

Abstract

Plasma syndecan-1 decline was less pronounced in comatose OHCA patients treated with tocilizumab, without affecting sTM or PECAM-1. This contrasts previous IMICA findings of reduced systemic inflammation, vasopressor use, and myocardial injury, suggesting a complex relationship between inflammation and endothelial injury.Finally, PECAM-1 levels already at hospital admission had a moderate predictive value for mortality.

European Heart Journal Acute Cardiovascular Care
University of Copenhagen (DK), Copenhagen University Hospital (DK), Rigshospitalet (DK), IT University of Copenhagen (DK)
Good health and well-being
Openalex Percentile: Top 27%
Cardiac and Coronary Surgery Techniques
DOISourceOpenAlex
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Impact of Tocilizumab on endothelial function following Out-of-Hospital Cardiac Arrest: A Substudy of the IMICA randomized controlled Trial — Pär I. Johansson, Zakaria Alaoui-Ismaili, et al. · European Heart Journal Acute Cardiovascular Care (2026) | TGRS Research Map | TGRS