Short SCN5A Transcript Yields a NaV1.5 Fragment Influencing Cardiac Metabolism
APA-mediated regulation of <i>SCN5A</i> produces a short transcript encoding NaV1.5-NT, a novel mitochondrial-targeted peptide that supports cardiomyocyte metabolism. While the precise molecular mechanisms remain unresolved, these findings highlight an unforeseen alternative pathway for expanding <i>SCN5A</i>-mitochondrial crosstalk, with potential implications for metabolic changes in heart failure and arrhythmias.
Authors
- John W. Elrod (ORCID: https://orcid.org/0000-0003-3925-2224)
- Colleen S. Stein (ORCID: https://orcid.org/0000-0002-7676-6278)
- Bjorn K Knollmann
- Jared M. McLendon (ORCID: https://orcid.org/0000-0002-1002-5872)
- Elena Berezhnaya (ORCID: https://orcid.org/0000-0002-4733-5348)
- Nathan H. Witmer (ORCID: https://orcid.org/0000-0002-0369-0305)
- Ryan L. Boudreau (ORCID: https://orcid.org/0000-0002-9800-5349)
- Lili Wang
- Jin-Young Yoon
- Jasmyn M. Hoeger
- Barry L. London
Institutions
- University of Iowa (US)
- American Association of Colleges of Pharmacy (US)
- Fraternal Order of Eagles (US)
- Temple University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1161/circresaha.125.326973
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00