Inosine alleviates colorectal cancer liver metastasis by promoting M1 macrophage polarization and modulating the PI3K/AKT signaling pathway
Inosine exerted an inhibitory effect on colorectal cancer liver metastasis by skewing macrophages toward an M1 phenotype, dampening pro-inflammatory cytokine release, and regulating key genes via the PI3K/AKT pathway.
Authors
- Weizai shao
- Huai Xiao
- Yi-Hao Che (ORCID: https://orcid.org/0000-0002-5602-0268)
- Yuchen Ma (ORCID: https://orcid.org/0000-0002-8517-8793)
- Q M Yu
- Yadan Dong
- Caiyi Wang
- Heng Liu
- Zhengmei Shi
- Desheng Wan
Institutions
- Wakamoto Pharmaceutical (Japan) (JP)
- Dali University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fimmu.2026.1780972
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00