Anti-Xa Levels With Venous Thromboembolism Prophylaxis in Critical Care: A Systematic Review and Meta-Analysis
Less than half of critically ill patients achieved their prophylactic anti-Xa targets despite LMWH thromboprophylaxis. Subprophylactic anti-Xa levels may be associated with an increased risk of VTE. Male sex, increased weight, and elevated body mass index have a moderate certainty association with developing subprophylactic anti-Xa levels. This study highlights the clinical importance of anti-Xa level monitoring in critically ill adults and the need for a future randomized controlled trial to further evaluate this topic.
Authors
- D. R. Williamson
- Shannon M. Fernando (ORCID: https://orcid.org/0000-0003-4549-4289)
- M. Carrier
- Kevin Durr (ORCID: https://orcid.org/0000-0003-3866-0437)
- Jacob R. Gillen
- Rakesh Patel
- Carl Buccholz
- Alexandre Tran
- Alexa Ehlebracht
- Lauralyn McIntyre
- Salmaan Kanji
- Bram Rochwerg
- Deborah M. Siegal
Institutions
- University of Ottawa (CA)
- Queen's University (CA)
- Lakeridge Health (CA)
- Carilion Roanoke Memorial Hospital (US)
- Ottawa Hospital (CA)
- Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean (CA)
- Hôpital du Sacré-Cœur de Montréal (CA)
- Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal (CA)
- Millennium Charter Academy (US)
- Impact (CA)
- Ottawa Hospital Research Institute (CA)
- Carilion Clinic (US)
- Université de Montréal (CA)
- Hamilton Health Sciences (CA)
- Virginia Tech (US)
- McMaster University (CA)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1097/ccm.0000000000007079
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00