A lactylation modification-related prediction model for the diagnosis of ulcerative colitis based on machine learning
By applying machine learning methods to analyze sequencing data, we identified core lactylation-related genes in UC and developed a diagnostic model with high predictive performance. Furthermore, based on scRNA-seq data, we investigated lactylation modifications across seven types of immune cells in UC patients, providing valuable insights into the interplay between lactylation and immune cells in UC.
Authors
- Yanxiang Zhou
- Jiao Li
- Jian Liu
- Xiaoyun Kang
Institutions
- Wuhan University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fimmu.2026.1717232
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China