A lactylation modification-related prediction model for the diagnosis of ulcerative colitis based on machine learning

By applying machine learning methods to analyze sequencing data, we identified core lactylation-related genes in UC and developed a diagnostic model with high predictive performance. Furthermore, based on scRNA-seq data, we investigated lactylation modifications across seven types of immune cells in UC patients, providing valuable insights into the interplay between lactylation and immune cells in UC.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-03-11
DOI
https://doi.org/10.3389/fimmu.2026.1717232
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
0.00

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article

A lactylation modification-related prediction model for the diagnosis of ulcerative colitis based on machine learning

Yanxiang Zhou, Jiao Li, Jian Liu, Xiaoyun Kang
Frontiers in Immunology
Immune cells in cancer
article

A lactylation modification-related prediction model for the diagnosis of ulcerative colitis based on machine learning

Yanxiang Zhou, Jiao Li, Jian Liu, Xiaoyun Kang
article en

Abstract

By applying machine learning methods to analyze sequencing data, we identified core lactylation-related genes in UC and developed a diagnostic model with high predictive performance. Furthermore, based on scRNA-seq data, we investigated lactylation modifications across seven types of immune cells in UC patients, providing valuable insights into the interplay between lactylation and immune cells in UC.

Frontiers in ImmunologyVol. 17
Wuhan University (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), Renmin Hospital of Wuhan University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 26%
Immune cells in cancer
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