A Sandwich-Structured Drug-Loaded Polyester Dressing with Unidirectional Liquid Transport Capability for Exudate Management and Wound Healing

Excessive wound exudate and bacterial infection are adverse for wound healing. Therefore, a sandwich-structured PTF-NEDDP@FT9%-PLA nanofiber dressing with both wettability and pore size design was fabricated by electrospinning, which could solve comprehensive healing problems in a one-stop manner. When hydrophilic NEDDP@FT (iterative polyester (NEDDP) modified by forsythin) is integrated with the hydrophobic poly(trimethylene 2,5-furandicarboxylate) PTF layer, a Janus structure is formed, which facilitates the efficient removal of wound exudate. In addition, the degressive pore size from the inner layer (PTF) to the outer layer (polylactic acid, PLA) further enhanced the exudate management performance. Furthermore, FT provides an excellent antibacterial property (99.30%), antioxidant property (89.56%), and biocompatibility (94.23%) and significantly reduces the expression of anti-inflammatory factors (IL-6 and TNF-α). The full-thickness skin defect model in mice demonstrated that the wound healing rate of the drug-loaded sandwich-structured dressing reached 96.1%, and a regenerated epidermis appeared near the wound. In summary, the sandwich-structured PTF-NEDDP@FT9%-PLA nanofiber dressing holds significant promise for effectively managing wound exudate and accelerating the wound healing process.