First metagenomic analysis of age-associated changes in the gut microbiome among healthy Saudi adults: SAMS pilot study
In healthy Saudi adults, increasing age was associated with higher microbial diversity and compositional shifts at phylum and species levels. These age-associated microbial taxa might represent biomarkers of healthy aging and suggest an enhanced community capacity for short-chain fatty acids (SCFAs) production, a hypothesis warranting validation through future functional analyses.
Authors
- A. Al-Hazzani (ORCID: https://orcid.org/0009-0000-0576-2694)
- Roua Almatrafi (ORCID: https://orcid.org/0000-0002-0293-1381)
- Majed F. Alghoribi (ORCID: https://orcid.org/0000-0002-2122-8640)
- Raniah S. Alotibi (ORCID: https://orcid.org/0009-0005-2531-9258)
- Nasser Alqurainy (ORCID: https://orcid.org/0009-0001-3663-2865)
- Marwh G. Aldriwesh (ORCID: https://orcid.org/0000-0001-6319-2669)
- Reham Ajina
- Ghaida Almuneef
- Shatha Alrabiah
- Assad M. Arafah
- Abdulrahman Alasiri
- Maymounah Hakami
Institutions
- King Saud bin Abdulaziz University for Health Sciences (SA)
- King Saud University (SA)
- King Abdullah International Medical Research Center (SA)
- National Guard Health Affairs (SA)
Publication Details
- Journal
- Frontiers in Aging
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fragi.2026.1733638
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of National Guard Health Affairs
- King Abdullah International Medical Research Center
- King Saud bin Abdulaziz University for Health Science