Unraveling the dual immunomodulatory and immunogenic roles of the central conserved cysteine-rich region in respiratory syncytial virus G protein
We propose a redox‑dependent immune‑evasion model in which secreted, monomeric G mediates transient immunosuppression that is halted by disulfide‑driven oligomerization of membrane‑bound G and F proteins. These findings support a mechanistic association between the redox state of RSV G, its oligomeric behavior, and its immunomodulatory properties.
Authors
- Ana Paletta (ORCID: https://orcid.org/0000-0003-2181-8488)
- Federico Birnberg-Weiss
- Cecilia Arahí Prato (ORCID: https://orcid.org/0009-0003-2082-5886)
- Julia Dvorkin (ORCID: https://orcid.org/0000-0001-7182-5681)
- Alana B. Byrne (ORCID: https://orcid.org/0000-0001-9370-1073)
- Carla Jimena Goldin (ORCID: https://orcid.org/0000-0001-8996-4153)
- Ari Zeida (ORCID: https://orcid.org/0000-0003-0938-287X)
- Santiago Sastre (ORCID: https://orcid.org/0000-0001-8801-3946)
- María Virginia Tribulatti
- Analia Boudgouste
- Pablo Pakciarz
- Damian Alvarez-Paggi
- Fernando Pedro Polack
- Gabriela Cristina Fernández
- Juan Gutman
- Mauricio Tomas Caballero
- Verónica Inés Landoni
- Sebastián Andrés Esperante
Institutions
- Academia Nacional de Medicina (AR)
- Universidad de la República de Uruguay (UY)
- Infant Foundation (AR)
- Universidad Nacional de San Martín (PE)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fmicb.2026.1794062
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Agencia Nacional de Promoción Científica y Tecnológica