Effectiveness and safety of perampanel in patients with lennox-gastaut syndrome: a single-arm meta-analysis with meta-regression and sensitivity analyses

Perampanel demonstrates clinically meaningful seizure reduction in LGS with modest seizure-freedom and a behaviorally skewed safety profile. Despite heterogeneity and mostly retrospective data, findings support adjunctive use and highlight the need for larger, high-quality RCTs.

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Publication Details

Journal
Epilepsy & Behavior
Published
2026-03-11
DOI
https://doi.org/10.1016/j.yebeh.2026.110972
Primary Topic
Gastroesophageal reflux and treatments
Type
article
Field-Weighted Citation Impact
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article

Effectiveness and safety of perampanel in patients with lennox-gastaut syndrome: a single-arm meta-analysis with meta-regression and sensitivity analyses

GABRIELA DAS GRAÇAS DOS SANTOS CAROLINO, Amanda Alves Rabelo, Júlia Fraga Castro e Oliveira, Yasmim De Souza Nunes et al.
Epilepsy & Behavior
Gastroesophageal reflux and treatments
article

Effectiveness and safety of perampanel in patients with lennox-gastaut syndrome: a single-arm meta-analysis with meta-regression and sensitivity analyses

GABRIELA DAS GRAÇAS DOS SANTOS CAROLINO, Amanda Alves Rabelo, Júlia Fraga Castro e Oliveira, Yasmim De Souza Nunes, Daniel Correa de Castro, Carolina Alves Corrêa, Bernhard J. Steinhoff
article en

Abstract

Perampanel demonstrates clinically meaningful seizure reduction in LGS with modest seizure-freedom and a behaviorally skewed safety profile. Despite heterogeneity and mostly retrospective data, findings support adjunctive use and highlight the need for larger, high-quality RCTs.

Epilepsy & BehaviorVol. 179
Universidade Federal de Juiz de Fora (BR), Pontifícia Universidade Católica de Minas Gerais (BR), Faculdade de Ciências Médicas de Minas Gerais (BR), Universidade Sagrado Coração (BR), Diakonie Kork (DE)
Openalex Percentile: Top 26%
Gastroesophageal reflux and treatments
DOIOpen Access PDFOpenAlex
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