A case of trigeminal nerve neurosarcoidosis initially presenting with isolated neurological findings mimicking trigeminal schwannoma: a case report and review of the literature

This case highlights the diagnostic challenges of trigeminal nerve lesion. There are no specific imaging features on magnetic resonance imaging that reliably distinguish neurosarcoidosis from tumors such as schwannomas or meningiomas. Therefore, neurosarcoidosis should be included in the differential diagnosis of contrast-enhancing Meckel's cave masses, even in patients without known systemic sarcoidosis. Tissue biopsy can be invaluable in determining inflammatory lesions and preventing overly aggressive resections. Once diagnosed, neurosarcoidosis is typically managed with high-dose corticosteroids and follow-up, often leading to symptom improvement. Timely histological confirmation and collaborative, multidisciplinary management are essential for achieving correct diagnosis and favorable outcomes.

Authors

Institutions

Publication Details

Journal
Journal of Medical Case Reports
Published
2026-03-11
DOI
https://doi.org/10.1186/s13256-026-05927-x
Primary Topic
Sarcoidosis and Beryllium Toxicity Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

A case of trigeminal nerve neurosarcoidosis initially presenting with isolated neurological findings mimicking trigeminal schwannoma: a case report and review of the literature

Hamza Adel Salim, Maria Gule-Monroe, Heba Al Qudah, Ahmed Msherghi et al.
Journal of Medical Case Reports
Sarcoidosis and Beryllium Toxicity Research
article

A case of trigeminal nerve neurosarcoidosis initially presenting with isolated neurological findings mimicking trigeminal schwannoma: a case report and review of the literature

Hamza Adel Salim, Maria Gule-Monroe, Heba Al Qudah, Ahmed Msherghi, Ceylan Altintas Taslicay, Muhammed Elhadi, Sahar Alizada, Max Wintermark
article en

Abstract

This case highlights the diagnostic challenges of trigeminal nerve lesion. There are no specific imaging features on magnetic resonance imaging that reliably distinguish neurosarcoidosis from tumors such as schwannomas or meningiomas. Therefore, neurosarcoidosis should be included in the differential diagnosis of contrast-enhancing Meckel's cave masses, even in patients without known systemic sarcoidosis. Tissue biopsy can be invaluable in determining inflammatory lesions and preventing overly aggressive resections. Once diagnosed, neurosarcoidosis is typically managed with high-dose corticosteroids and follow-up, often leading to symptom improvement. Timely histological confirmation and collaborative, multidisciplinary management are essential for achieving correct diagnosis and favorable outcomes.

Journal of Medical Case Reports
The University of Texas MD Anderson Cancer Center (US), Korea University (JP)
Openalex Percentile: Top 26%
Sarcoidosis and Beryllium Toxicity Research
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.