Riboflavin (VB2) inhibits hepatocellular carcinogenesis by enhancing retinol metabolism and suppressing cell proliferation in Hras12V transgenic mice
To our knowledge, this study is the first to demonstrate <i>in vivo</i> that VB2 alone can significantly suppress hepatic tumorigenesis by enhancing retinol metabolism and inhibiting cell proliferation pathways, highlighting its potential as a chemopreventive agent for HCC.
Authors
- Jiayu Song (ORCID: https://orcid.org/0000-0003-0316-0774)
- Rujiao Jiang
- Jie Chen (ORCID: https://orcid.org/0000-0003-3435-0351)
- Aiguo Wang (ORCID: https://orcid.org/0000-0001-5022-3585)
- Nan Mao
- Ning Wang
- Huiling Li
Institutions
- Dalian Medical University (CN)
- Institute of Laboratory Animal Science (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fonc.2026.1773897
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Dalian Medical University