Cerebral amebiasis due to <i>Acanthamoeba</i> sp. in a patient with complete gp91 <i>phox</i> deficiency
Rare variants in <i>CYBB</i> (encoding gp91 <sup><i>phox</i></sup> ) are responsible for chronic granulomatous disease. We report a patient affected by multiple cerebral abscesses caused by <i>Acanthamoeba</i> <i>sp</i>. and complete gp91 <sup><i>phox</i></sup> deficiency. The respiratory burst evaluation is recommended in any child with a deep abscess.
Authors
- Nathalie Boddaert (ORCID: https://orcid.org/0000-0003-0991-7774)
- Marie Roelens
- Jérémie Rosain (ORCID: https://orcid.org/0000-0002-2822-161X)
- Liana Carausu
- Jacinta Bustamante (ORCID: https://orcid.org/0000-0002-3439-2482)
- Gislène Collobert
- Anna-Lena Neehus
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Hospital for Sick Children Pediatric Center (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- Dana-Farber Cancer Institute (US)
- Centre Hospitalier Régional Universitaire de Brest (FR)
- Human Genetic of Infectious Diseases (FR)
- Institut des Maladies Génétiques Imagine (FR)
- Rockefeller University (US)
Publication Details
- Journal
- Journal of Human Immunity
- Published
- 2026-02-12
- DOI
- https://doi.org/10.70962/jhi.20250160
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.00