Association of proteins involved in fetal lung development with respiratory outcomes in infancy
In healthy infants, we found no clear association between the identified protein profiles and respiratory outcomes. However, we observed a trend for reduced tPTEF/tE in the low VEGF-A levels profile, which could indicate that some protein profiles may be associated with an increased risk of impaired lung function in infancy. This might be relevant in populations with additional risk factors such as prematurity or maternal asthma.
Authors
- Carmen Streibel (ORCID: https://orcid.org/0000-0002-4781-3418)
- Loretta Müller (ORCID: https://orcid.org/0000-0002-3145-1483)
- Primo Schär (ORCID: https://orcid.org/0000-0003-1843-6147)
- Xenia Bovermann
- Philipp Latzin (ORCID: https://orcid.org/0000-0002-5239-1571)
- Céline Rüttimann (ORCID: https://orcid.org/0009-0007-9537-5487)
- David Schürmann (ORCID: https://orcid.org/0000-0003-2904-1378)
- Fiona J. Beck (ORCID: https://orcid.org/0000-0001-9631-938X)
- Carmen Casaulta (ORCID: https://orcid.org/0000-0003-4754-1608)
- Marc‐Alexander Oestreich (ORCID: https://orcid.org/0000-0001-9641-3691)
- Sophie Yammine (ORCID: https://orcid.org/0000-0001-7720-3445)
- Ruth Steinberg (ORCID: https://orcid.org/0000-0003-4108-6085)
- Marion Curdy (ORCID: https://orcid.org/0000-0002-6034-9103)
- Bettina Frauchiger (ORCID: https://orcid.org/0000-0002-9519-9328)
- Kees de Hoogh (ORCID: https://orcid.org/0000-0001-5974-2007)
- Andrea Marten (ORCID: https://orcid.org/0009-0008-3853-1276)
- Noëmi Künstle (ORCID: https://orcid.org/0009-0000-8148-709X)
- Elisabeth Kieninger (ORCID: https://orcid.org/0000-0003-1741-5221)
- Florian Wyler (ORCID: https://orcid.org/0000-0002-1232-1392)
- Olga Gorlanova (ORCID: https://orcid.org/0000-0002-3153-7404)
- Insa Korten (ORCID: https://orcid.org/0000-0002-6184-5280)
- Jakob Usemann (ORCID: https://orcid.org/0000-0002-9987-2866)
- Uri Nahum (ORCID: https://orcid.org/0000-0001-6186-1830)
- Léa Kim-Mi Ho Dac
- Malena Gwerder
- Pablo Sinues
- Benjamin Stoecklin
- Pawan Sharma
- Carla Rebeca Da Silva Sena
- Sven Schulzke
- Martin Röösli
- Urs Frey
Institutions
- University of Bern (CH)
- Swiss Tropical and Public Health Institute (CH)
- University of Basel (CH)
- University Hospital of Bern (CH)
- University Children’s Hospital Bern (CH)
- University Children’s Hospital Basel (CH)
- Temple University (US)
Publication Details
- Journal
- Respiratory Medicine
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1016/j.rmed.2026.108773
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung