Signal or noise? Evaluating commonly used attribution methods for explaining deep neural networks in electrocardiogram classification

Attribution methods demonstrated limited reliability, instability across model variants and incomplete dependence on learned parameters, constraining their utility in high-stakes settings such as healthcare. These findings suggest that attribution techniques should be used cautiously and supported by task-specific sanity checks. Approaches grounded in rigorous validation, inherently interpretable modelling or counterfactual explanations may better support clinically meaningful insight.

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Publication Details

Journal
European Heart Journal - Digital Health
Published
2026-03-04
DOI
https://doi.org/10.1093/ehjdh/ztag038
Primary Topic
ECG Monitoring and Analysis
Type
article
Field-Weighted Citation Impact
0.00

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article

Signal or noise? Evaluating commonly used attribution methods for explaining deep neural networks in electrocardiogram classification

Wouter A. C. van Amsterdam, Bauke Arends, R Van Es, Pim van der Harst et al.
European Heart Journal - Digital Health
ECG Monitoring and Analysis
article

Signal or noise? Evaluating commonly used attribution methods for explaining deep neural networks in electrocardiogram classification

Wouter A. C. van Amsterdam, Bauke Arends, R Van Es, Pim van der Harst, Maarten van Smeden, Rutger R van de Leur
article en

Abstract

Attribution methods demonstrated limited reliability, instability across model variants and incomplete dependence on learned parameters, constraining their utility in high-stakes settings such as healthcare. These findings suggest that attribution techniques should be used cautiously and supported by task-specific sanity checks. Approaches grounded in rigorous validation, inherently interpretable modelling or counterfactual explanations may better support clinically meaningful insight.

European Heart Journal - Digital HealthVol. 7(3)
Heidelberg University (DE), University Hospital Heidelberg (DE), University Medical Center Utrecht (NL)
ZonMw, Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Openalex Percentile: Top 35%
ECG Monitoring and Analysis
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