Signal or noise? Evaluating commonly used attribution methods for explaining deep neural networks in electrocardiogram classification
Attribution methods demonstrated limited reliability, instability across model variants and incomplete dependence on learned parameters, constraining their utility in high-stakes settings such as healthcare. These findings suggest that attribution techniques should be used cautiously and supported by task-specific sanity checks. Approaches grounded in rigorous validation, inherently interpretable modelling or counterfactual explanations may better support clinically meaningful insight.
Authors
- Wouter A. C. van Amsterdam (ORCID: https://orcid.org/0000-0002-3181-0810)
- Bauke Arends (ORCID: https://orcid.org/0009-0009-7494-4542)
- R Van Es
- Pim van der Harst
- Maarten van Smeden
- Rutger R van de Leur
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- European Heart Journal - Digital Health
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1093/ehjdh/ztag038
- Primary Topic
- ECG Monitoring and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek