Fecal microbiota transplantation ameliorates alcohol-associated liver disease through coordinated restoration of short-chain fatty acid and α-linolenic acid signaling
Our findings demonstrate that FMT from healthy donors ameliorates ALD by restoring critical microbial metabolic functions, particularly SCFA production and ALA-related pathways. These results highlight microbial metabolic function as a promising therapeutic target for microbiome-based interventions in ALD.
Authors
- Rina Su (ORCID: https://orcid.org/0000-0003-4578-2993)
- Jianjun Wang (ORCID: https://orcid.org/0000-0001-7039-7136)
- Jing Li (ORCID: https://orcid.org/0000-0002-2256-9818)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Ying Liu (ORCID: https://orcid.org/0000-0002-1312-0146)
- Junbai Ma
- Shaoqi Yang
- Xiaoxia Zhang
- Qian Mai
- Tian Ma
- Qian Ma
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fmicb.2026.1744446
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00