Baseline FDG-PET Brain hypometabolism as a predictive biomarker of cognitive decline and Alzheimer’s disease risk
We found that brain glucose metabolism is a notable determinant of cognitive decline progression, especially for Alzheimer's disease risk, providing quantifiable metabolic protection against decline. Our results demonstrate brain glucose hypometabolic findings from baseline FDG-PET as a precision biomarker for therapeutic stratification and support further interventions for cognitive preservation for further research, validation and development purposes that should be further evaluated and investigated in further clinical trials that may lead to better preventive and therapeutic benefits for cognitive functions preservation and prevention of cognitive decline process in high-risk individuals.
Authors
- James Milburn (ORCID: https://orcid.org/0000-0003-3403-2628)
- Mustafa S. Alhasan (ORCID: https://orcid.org/0009-0002-4401-5127)
- Seham Hamoud (ORCID: https://orcid.org/0009-0004-7907-0403)
- Omar Alharthi (ORCID: https://orcid.org/0000-0002-7743-104X)
- Ayman S. Alhasan (ORCID: https://orcid.org/0000-0001-8879-4017)
- Muhammed Amir Essibayi (ORCID: https://orcid.org/0000-0001-8325-2382)
- Fabrício Stewan Feltrin (ORCID: https://orcid.org/0000-0001-6783-7655)
- Dhairya A. Lakhani (ORCID: https://orcid.org/0000-0001-7577-1887)
- Yasir Hassan Elhassan (ORCID: https://orcid.org/0000-0003-0196-5413)
- Abdullah Almaghraby (ORCID: https://orcid.org/0000-0003-4956-2613)
- Ahmed Y. Azzam
- Mohammad Khalil
- Sumit Singh
- Hadeel A. Ghunaim
Institutions
- West Virginia University (US)
- University of Suffolk (GB)
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- King Abdulaziz University (SA)
- Umm al-Qura University (SA)
- Taibah University (SA)
- Ochsner Medical Center (US)
- Blanchette Rockefeller Neurosciences Institute (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- The journal of nutrition health & aging
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1016/j.jnha.2026.100823
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00