Tissue-specific epigenetic regulation of fat metabolism in pigs through integrated analysis of DNA methylation and gene expression networks
Across liver, backfat, and loin, DNA methylation modulates transcriptional programs in a tissue-dependent manner, prioritizing pathways central to lipid handling, extracellular matrix remodeling, and muscle function. This integrated multi-omics framework highlights candidate epigenetic markers and regulatory modules with potential utility for improving pork quality traits through selection or management strategies.
Authors
- Rajesh Kumar Pathak (ORCID: https://orcid.org/0000-0003-3835-8430)
- Byeonghwi Lim (ORCID: https://orcid.org/0000-0001-8489-0044)
- D. E. Kim
- J. H. Park
- Jun‐Mo Kim (ORCID: https://orcid.org/0000-0002-6934-398X)
- Woncheoul Park
Institutions
- Iowa State University (US)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- National Institute of Animal Science (KR)
- Chung-Ang University (KR)
- Jeju National University (KR)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1186/s40104-025-01347-x
- Primary Topic
- Genetic Mapping and Diversity in Plants and Animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Rural Development Administration
- National Research Foundation of Korea