Estrogen Metabolism–Related Lifestyle Score and Risk of Postmenopausal Breast, Endometrial, and Ovarian Cancers: Findings from Two Large Prospective Cohort Studies
Elevated estrogen 2-OH has been linked to reduced breast cancer risk. We showed that lifestyle patterns increasing the 2-OH EM/parent E ratio were associated with lower postmenopausal breast and endometrial cancer risk. Our findings suggest that targeted lifestyle modifications may benefit postmenopausal women with a low 2-OH EM/parent E ratio.
Authors
- Fangcheng Yuan (ORCID: https://orcid.org/0000-0002-8443-6754)
- Eleanor L. Watts (ORCID: https://orcid.org/0000-0001-9229-2589)
- Nikhil K. Khankari (ORCID: https://orcid.org/0000-0002-8802-4431)
- Jirong Long (ORCID: https://orcid.org/0000-0002-7433-9766)
- Wen‐Yi Huang (ORCID: https://orcid.org/0000-0002-4440-3368)
- X-O Shu
- X. Xu
- Loren Lipworth
- Ran Tao
- Wei Zheng
- Steven C. Moore
- Hui Cai
Institutions
- Leidos (United States) (US)
- National Cancer Institute (US)
- Department of Health and Human Services (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cancer Prevention Research
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1158/1940-6207.capr-25-0382
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00