GuiLingJi ameliorates mild cognitive impairment by targeting unsaturated fatty acid metabolism to inhibit GPR120/NF-κB mediated neuroinflammation
These findings demonstrate that GLJ alleviates MCI symptoms, at least in part, by modulating fatty acid metabolism and suppressing neuroinflammation <i>via</i> the GPR120/NF-κB pathway. This study supports GLJ as a promising proprietary TCM formulation for MCI treatment.
Authors
- Xuemei Qin (ORCID: https://orcid.org/0000-0002-0020-3364)
- Xubo Gao (ORCID: https://orcid.org/0000-0003-2458-3063)
- Shuting Yu (ORCID: https://orcid.org/0000-0003-2074-7120)
- Lingfan Ni
- Jingchao Shi
Institutions
- Shanxi University (CN)
- Xinjiang Institute of Materia Medica (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fphar.2026.1729885
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanxi University
- Scientific Instrument Center, SXU