Therapeutic misalignment averted by clonal evolutionary evidence: molecular confirmation of hepatic metastasis in SMARCA4-deficient non-small cell lung cancer initially misdiagnosed as resectable cholangiocarcinoma

This study provides the first genomic evidence of shared and divergent somatic mutations in <i>SMARCA4</i>-dNSCLC and its hepatic metastasis. Clonal evolutionary analysis confirmed the diagnosis of <i>SMARCA4</i>-dNSCLC with hepatic metastasis, resolving diagnostic challenges and supporting precision therapy.