Tuberculosis preventive therapy in postpartum women with HIV modifies M. tuberculosis-specific and nonspecific immune responses
TPT was associated with a significant decrease in TB-specific T cell responses, including Tconv but mostly unconventional T cells, suggesting an important role of unconventional T cell memory in the control of TB infection. The prominent decrease of granzyme B-expressing T cells in response to TPT highlighted the importance of granzyme B in the maintenance of LTBI.
Authors
- Allen Matubu (ORCID: https://orcid.org/0000-0001-5361-7686)
- A Violari
- Gaerolwe Masheto (ORCID: https://orcid.org/0000-0002-2388-9637)
- Gerhard Barnard Theron (ORCID: https://orcid.org/0000-0001-8888-1436)
- Deo Wabwire (ORCID: https://orcid.org/0009-0001-8923-2005)
- Grace Montepiedra (ORCID: https://orcid.org/0000-0002-6866-4335)
- Amita Gupta
- Lynda Stranix-Chibanda
- Damayanti Yengkhom
- Adriana Weinberg
Institutions
- Johns Hopkins University (US)
- University of Zimbabwe (ZW)
- Stellenbosch University (ZA)
- Johns Hopkins Medicine (US)
- Cancer Research And Biostatistics (US)
- MUJHU Research Collaboration (UG)
- Botswana Harvard AIDS Institute Partnership (BW)
- Perinatal HIV Research Unit (ZA)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fimmu.2026.1722621
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Johns Hopkins University
- Chiang Mai University
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases