Age-dependent immune profiles and variant-driven humoral alterations across two SARS-CoV-2 epidemic phases
Immunological responses to SARS-CoV-2 and its variants differ substantially with age and immune history. Vaccination, especially in older adults, partially compensates for age-related immune decline and enhances cross-protection against immune-evasive variants such as XBB.1.5, supporting age-tailored vaccination and booster strategies.
Authors
- Mingyan Dai
- Q J Li
- Nana Guo
- Yajing Wu
- Shiyou Liu
- Guangyue Han
- Xu Han
Institutions
- Hebei Medical University (CN)
- Hebei North University (CN)
- Hebei Provincial Center for Disease Control and Prevention (CN)
- Hebei University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fimmu.2026.1776854
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00