Flow Cytometric Profiling Reveals Platelet Dysfunction and Impaired Immune Communication in Acute and Chronic Cerebrovascular Disease

Patients with cerebrovascular disorders show distinct platelet activation patterns and impaired immune crosstalk. Reduced P-selectin expression and decreased lymphocyte-platelet aggregation, especially T-cell, indicate sustained platelet dysfunction and disrupted neuroinflammatory regulation. Flow cytometric assessment of these parameters provides valuable insight into neurovascular diseases at different stages and potential biomarkers for disease monitoring.