Acetamiprid exerts sex-specific effects on adipose tissue of subjects with severe obesity
These results show that the neonicotinoid ACE worsens AT dysfunction via inflammatory and metabolic pathways in a sex-specific way, likely leading to different risks of obesity-related complications. Overall, these findings provide a mechanistic basis for understanding the toxicological risk of neonicotinoids, highlighting the importance of sex-specific assessment in evaluating metabolic risks of environmental pesticide exposure.
Authors
- Valentina Monteleone (ORCID: https://orcid.org/0000-0002-0708-4687)
- Beatrice Scazzocchio (ORCID: https://orcid.org/0000-0002-5123-3897)
- Gianfranço Silecchia (ORCID: https://orcid.org/0000-0003-2356-0505)
- Carmela Santangelo (ORCID: https://orcid.org/0000-0002-4309-1745)
- Roberta De Simone (ORCID: https://orcid.org/0000-0001-5130-1303)
- Sabrina Tait (ORCID: https://orcid.org/0000-0001-8029-8625)
- Massimo D’Archivio (ORCID: https://orcid.org/0000-0001-8104-3421)
- Annalisa Silenzi (ORCID: https://orcid.org/0000-0001-9589-7460)
- Niccolò Petrucciani (ORCID: https://orcid.org/0000-0002-4639-5613)
- Sara Manella
- Giulia Zanchi
- Maria Antonietta Ajmone-Cat
- Alessia Tammaro
- Rosaria Varì
Institutions
- University of Rome Tor Vergata (IT)
- Istituto Superiore di Sanità (IT)
- St Andrew’s Hospital (AU)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/ftox.2026.1769863
- Primary Topic
- Insect and Pesticide Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission