A Research Classification for Long COVID: Symptom Frequency and Severity Improve Accuracy of Machine Learning Models

Summary Long COVID definitions based solely on symptom occurrence may reduce diagnostic specificity. Machine‐learning models incorporating symptom frequency and severity outperformed occurrence‐only models. Composite scoring achieved 90.12% accuracy compared with 88.73% for occurrence‐based scoring. Composite models required fewer predictive symptoms, indicating greater efficiency. Measuring symptom burden improves the precision of research classification for Long COVID.

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Publication Details

Journal
Chronic Diseases and Translational Medicine
Published
2026-03-09
DOI
https://doi.org/10.1002/cdt3.70044
Primary Topic
Long-Term Effects of COVID-19
Type
article
Field-Weighted Citation Impact
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article

A Research Classification for Long COVID: Symptom Frequency and Severity Improve Accuracy of Machine Learning Models

Ben Z. Katz, Lauren Ruesink, Jacob Furst, Leonard A. Jason
Chronic Diseases and Translational Medicine
Long-Term Effects of COVID-19
article

A Research Classification for Long COVID: Symptom Frequency and Severity Improve Accuracy of Machine Learning Models

Ben Z. Katz, Lauren Ruesink, Jacob Furst, Leonard A. Jason
article en

Abstract

Summary Long COVID definitions based solely on symptom occurrence may reduce diagnostic specificity. Machine‐learning models incorporating symptom frequency and severity outperformed occurrence‐only models. Composite scoring achieved 90.12% accuracy compared with 88.73% for occurrence‐based scoring. Composite models required fewer predictive symptoms, indicating greater efficiency. Measuring symptom burden improves the precision of research classification for Long COVID.

Chronic Diseases and Translational Medicine
DePaul University (US), Lurie Children's Hospital (US)
Openalex Percentile: Top 35%
Long-Term Effects of COVID-19
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