The multiomics blueprint of the individual with the most extreme lifespan
Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world's oldest living person, interrogating her genome, transcriptome, metabolome, proteome, microbiome, and epigenome, comparing the results with larger matched cohorts. The emerging picture highlights different pathways attributed to each process: the record-breaking advanced age is manifested by telomere attrition, abnormal B cell population, and clonal hematopoiesis, whereas absence of typical age-associated diseases is associated with rare European-population genetic variants, low inflammation levels, a rejuvenated bacteriome, and a younger epigenome. These findings provide a fresh look at human aging biology, suggesting biomarkers for healthy aging, and potential strategies to increase life expectancy. The extrapolation of our results to the general population will require larger cohorts and longitudinal prospective studies to design potential anti-aging interventions.
Authors
- Núria Amigó (ORCID: https://orcid.org/0000-0002-0116-9145)
- Toni Gabaldón (ORCID: https://orcid.org/0000-0003-0019-1735)
- Claudia Vasallo (ORCID: https://orcid.org/0000-0002-0043-0882)
- Xavier Aldeguer (ORCID: https://orcid.org/0000-0003-4597-8339)
- Lauro Sumoy (ORCID: https://orcid.org/0000-0003-0005-4618)
- Pamela Acha (ORCID: https://orcid.org/0000-0002-4528-1219)
- Mauricio Moldes (ORCID: https://orcid.org/0000-0001-5455-7769)
- Carles Arribas
- Verónica García Dávalos
- Caterina Mata (ORCID: https://orcid.org/0000-0001-9403-7434)
- Isabel Granada (ORCID: https://orcid.org/0000-0002-4275-0104)
- Fernando Setién (ORCID: https://orcid.org/0000-0002-4061-4635)
- Fabio Barteri (ORCID: https://orcid.org/0000-0003-0844-512X)
- Raquel Pluvinet (ORCID: https://orcid.org/0000-0002-4955-8238)
- Gerardo Ferrer (ORCID: https://orcid.org/0000-0002-4084-6815)
- Carolina De La Torre (ORCID: https://orcid.org/0000-0001-8918-2266)
- Francesc Gessé Solé
- Marc Llirós (ORCID: https://orcid.org/0000-0001-8456-4230)
- Donald J. L. Jones (ORCID: https://orcid.org/0000-0001-6583-870X)
- Hafid Laayouni (ORCID: https://orcid.org/0000-0003-1297-5078)
- Elisabetta Mereu (ORCID: https://orcid.org/0000-0001-6101-8472)
- Sara Samino (ORCID: https://orcid.org/0000-0001-8371-679X)
- Aleix Lluansí (ORCID: https://orcid.org/0000-0002-2328-6780)
- Gerard Muntané (ORCID: https://orcid.org/0000-0003-1541-8365)
- Arcadi Segura i Navarro
- Josep Ribalta (ORCID: https://orcid.org/0000-0002-8879-4719)
- M. Mallo
- Paulene A. Quinn
- M. Guardiola
- Sara Peregrina
- Meritxell Pujolassos
- Pol Torne
- Jose Oviedo (ORCID: https://orcid.org/0009-0007-8248-2208)
- Bernardo Lemos
- Marta Torrubiano
- Kamal A. Khidir
- Thong Huy Cao
- Ignacio Campillo Marcos
- Alberto Bueno Costa
- Aleix Noguera Castells
- Francisco Villavicencio Goula
- Salvador Macip
- Librado Jesús García Gil
- Manel Esteller
- Marta Massip Salcedo
- Marta Casado Pelaez
- Julia Rius Bonet
- Carlos A. García Prieto
- Paula Martínez
- Robert Carrera Torres
- Carlos Quero Dotor
- Raúl Sánchez Vázquez
- Eva Crespo García
- Eloy Santos Pujol
- Oscar Yanes
- Eva Brigos Barril
- Natalie S. Coles
- Maria A. Blasco
Publication Details
- Journal
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
- Published
- 2025-10-21
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00