Maternal and child immune profiles are associated with neurometabolite measures of early-life neuroinflammation in children who are HIV-exposed and uninfected: a South African birth cohort
In this South African cohort, HIV exposure-specific associations were observed between certain mother and child immune markers and child neurometabolite ratios at 2-3 years. Larger, longitudinal neuroimaging studies integrating neurodevelopmental outcomes are needed to clarify mechanisms and clinical implications.
Authors
- Catherine J. Wedderburn (ORCID: https://orcid.org/0000-0002-4887-1644)
- Tusekile S. Kangwa (ORCID: https://orcid.org/0000-0003-2638-6725)
- Nadia Hoffman (ORCID: https://orcid.org/0000-0002-7269-1416)
- Sivenesi Subramoney (ORCID: https://orcid.org/0000-0001-8947-439X)
- Cesc Bertran-Cobo (ORCID: https://orcid.org/0000-0001-9286-9595)
- Frances Robertson (ORCID: https://orcid.org/0000-0002-4392-7012)
- J. S. Annandale (ORCID: https://orcid.org/0000-0002-9345-9309)
- Kirsten A. Donald (ORCID: https://orcid.org/0000-0002-0276-9660)
- Katherine L. Narr (ORCID: https://orcid.org/0000-0002-9396-7936)
- Shantanu H. Joshi
- Petrus J. W. Naudé
- Heather J. Zar
- Dan J. Stein
Institutions
- University of Cape Town (ZA)
- University of California, Los Angeles (US)
- London School of Hygiene & Tropical Medicine (GB)
- Neurobehavioral Systems (US)
- Red Cross War Memorial Children's Hospital (ZA)
- University of the Western Cape (ZA)
Publication Details
- Journal
- Wellcome Open Research
- Published
- 2026-03-09
- DOI
- https://doi.org/10.12688/wellcomeopenres.24911.2
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00