Heterogeneous duplication and point mutation of ace-1 confer organophosphates and carbamates resistance to Anopheles sinensis field populations in Guizhou Province, China
Resistance to OPs and CBs is widespread in An. sinensis populations across Guizhou Province. Both heterogeneous duplication and point mutation of the ace-1 gene in An. sinensis likely contribute to resistance to OPs and CBs. These findings highlight the necessity of monitoring duplicated resistance alleles in natural populations to formulate region-specific resistance management strategies.
Authors
- Jinzhi Cheng
- Wei Li (ORCID: https://orcid.org/0000-0002-7941-7022)
- Jiale Chen (ORCID: https://orcid.org/0009-0005-3959-6416)
- Jiahong Wu (ORCID: https://orcid.org/0000-0001-6453-1570)
- Hai-Mo Shen
- Xi Yang
- Qiu-Guo Liang
- Qiu-Qiu Xiao
Institutions
- Guiyang Medical University (CN)
- National Institute for Parasitic Diseases (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- International Center for Tropical Agriculture (KE)
- Haikou Experimental Station (CN)
- Qiannan Normal College For Nationalities (CN)
Publication Details
- Journal
- Infectious Diseases of Poverty
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1186/s40249-026-01421-0
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centers for Disease Control and Prevention