Optimization-Driven Hybrid Machine Learning Framework for Brain Tumor Classification in MRI with Metaheuristic Feature Selection

<b>Background/Objectives:</b> Brain tumors are among the most severe neurological disorders, and their variability in size, morphology, and anatomical location complicates early and accurate diagnosis. Although magnetic resonance imaging (MRI) is the most reliable non-invasive modality for tumor detection, manual interpretation remains time-consuming, subjective, and susceptible to human error. This study aims to develop an optimization-driven hybrid machine learning framework for accurate and computationally efficient automatic brain tumor classification. <b>Methods:</b> The dataset includes 834 MRI images (583-training, 123-validation, 128-independent test). Because YOLOv11 detects tumor and non-tumor regions separately, the sample size doubled during region-based analysis, and all subsequent stages were conducted at the regions of interest (ROI) level. On the independent test set, YOLOv11 achieved 98.87% mAP@50, 98.54% precision, and 98.21% recall. The proposed framework combines automated tumor localization with image standardization using Gaussian noise reduction and bilinear interpolation. From the processed MR images, 39 entropy-based features were extracted. To enhance diagnostic performance and eliminate redundant information, the superb fairy-wren optimization algorithm (SFOA) was applied for feature selection and compared with particle swarm optimization (PSO), Harris hawk optimization (HHO), and puma optimization (PO). Final classification was primarily performed using k-nearest neighbors (kNN), while support vector machines (SVM) were used for comparative evaluation. <b>Results:</b> SFOA reduced the feature dimensionality from 39 to 5 features while achieving 99.20% classification accuracy on the independent test set. In comparison, PSO selected 10 features, HHO selected 6 features and PO selected 10 features, all achieving 98.45% accuracy. The best performance obtained with SVM was 98.45% accuracy (HHO-SVM), which remained lower than the 99.20% achieved by the proposed SFOA-kNN model. <b>Conclusions:</b> The results indicate that combining entropy-based feature extraction with SFOA-driven feature selection and kNN classification significantly enhances diagnostic accuracy while reducing computational complexity, highlighting the strong potential of the proposed framework for integration into computer-aided diagnosis systems to support clinical decision-making.